Part:BBa_K2152002:Experience

We confirmed the formation of EGF-loaded Curli biofilm through Congo Red dye (Figure 1) and Transmission electron microscopy (TEM) (Figure 2). "
Figure 1. Curli biofilms can be stained by Congo Red dye, which is a practical observing method for them [4]. The samples in two tubes are parallel. "
Figure 2. The Transmission electron microscopy (TEM) pictures of Curli fibers. (a) The EGF-loaded Curli biofilm encapsulates the entire cell, and (b) the fibers of EGF-loaded Curli biofilm are extremely robust that can withstand vigorous washing process. (c) The negative control that no Curli biofilm is present.

Applications of BBa_K2152002

We consider EGF-loaded Curli biofilm as a model to demonstrate the utility of the Biofilm-Based strategy to treating gut diseases like IBD. Our approach could potentially be applied to many other diseases where controlled therapeutic peptide release at a stable and continuous level.

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